What is filaggrin?
The filaggrin protein is what keeps your skin barrier intact. Low filaggrin means a leaky barrier, and a leaky barrier means dryness, irritation, and eczema. Supporting it both topically and internally is how you get real results.
Eczema isn’t a skin flaw. It’s a barrier problem.
In healthy skin…
Filaggrin helps pack skin cells tightly together, forming a strong, even outer barrier.
Breaks down into Natural Moisturizing Factors (NMFs) that retain water.
Protects against irritants, allergens, and microbes – keeping them out and moisture in.
In distressed skin…
Filaggrin levels are reduced: skin barrier weakens and less NMFs are produced to hold moisture.
Skin cells do not bind together as effectively, creating gaps in the barrier that allow moisture to escape and irritants to enter.
The skin struggles to retain hydration, leading to dryness and sensitivity
Low filaggrin triggers a vicious cycle.
A weakened barrier lets in irritants, which causes inflammation, which depletes filaggrin further, and around it goes.
HOW LOWERFILAGGRIN LEVELS TRIGGER ECZEMA FLARES
Step 1
Leakier barrier
”Brick wall” weakens; dryness rises
Step 2
Higher skin pH
Infection and colonization risk grows
Step 3
Inflammation & Itch
Scratching damages the barrier further
Step 4
Lower filaggrin
Inflammation signals suppress production
What is the role of L-Histidine?
Your body needs L-Histidine to produce filaggrin. It's a simple equation: more L-Histidine means more raw material to rebuild the barrier.
95%
improvement in eczema severity, dryness, itch & scaling
When L-Histidine supplementation was combined with the Codex Labs Eczema Relief Lotion, 100% of subjects saw an average eczema severity score decrease of 95% and an improvement across eczema severity, dryness, itch, scaling, and barrier function — in about 8 weeks.
Eczema severity, dryness, itch, and scaling all measurably improved when L-histidine and the right topicals worked together.
Your body uses L-Histidine to produce filaggrin and keep skin hydrated.
Less dryness, itch, and scaling — shown in clinical studies.
Paired with our Eczema Relief Lotion, 100% of infants and children improved with an average improvement of 95% in 8 weeks.
The topical routine: Boosting filaggrin from the outside
Cleanser • Daily
A wash that protects the microbiome instead of stripping it
Our Unscented Soap gently cleanses without stripping the lipids and natural moisturizing factors filaggrin produces. Unlike harsh, fragranced cleansers that raise skin pH and disrupt filaggrin processing, it helps preserve the skin's natural barrier.
Fragrance-free & non-stripping
Cleans without dissolving the ceramide “mortar” or the filaggrin breakdown products that hold water.
Respects the acid mantle
A pH-conscious formula keeps the slightly acidic surface filaggrin needs to be processed correctly.
Topical • Daily
A lotion that helps rebuild the barrier
Our Eczema Relief Lotion is formulated with barrier lipids and botanical actives to support the skin's own filaggrin cycle — not mask symptoms.
Reactivates filaggrin production
Helps restore filaggrin gene activity when inflammation suppresses expression, supporting healthy skin barrier function.
Calms the inflammation that suppresses it
Soothing botanicals quiet the Th2 signals that switch filaggrin genes down, breaking the vicious cycle.
Seals in moisture & restores pH
Ceramide-rich mortar locks water in and re-acidifies the surface, the conditions filaggrin needs to work.
The supplement: Boosting filaggrin from the inside
Supplement • Daily
Rebuild the skin barrier from within
Our Skin Barrier Support Supplements pair the amino acid behind filaggrin with antioxidants that protect it — feeding the barrier at its source.
Delivers age-appropriate dose of L-Histidine
The amino-acid building block the body uses to make filaggrin and its natural moisturizing factors.
Antioxidant support
Antioxidants such as vitamins C & E and M3 (Maqui, Matico, and Murtilla) help reduce oxidative stress and inflammation that can impair filaggrin expression and skin barrier function.
Clinically studied results
A 34% reduction in SCORAD eczema-severity score reported after 30 days of daily use with the supplement alone.
Barrier support works best from every direction: inside and out.
Fragrance-free & pH-balanced soap. Lukewarm water. Codex Labs’ Unscented Soap doesn’t strip skin hydration, oils or the skin microbiome.
Apply a nourishing oil that stimulates filaggrin production and seals in moisture, twice daily.
Daily L-Histidine at the studied dose, alongside any prescribed treatments.
BEST SELLERS
SKIN BARRIER PROTOCOL
SKIN BARRIER PROTOCOL
SKIN BARRIER PROTOCOL
SKIN BARRIER PROTOCOL
SKIN BARRIER PROTOCOL
Feed your filaggrin. Inside and out.
The Eczema Relief Skin Barrier Protocol pairs our pH-balanced Unscented Soap with a lotion that stimulates more filaggrin production and L-Histidine supplementation — a complete regimen built around the science of skin barrier repair.
Four things to remember:
Eczema is structural. A weakened skin barrier — leading to inflammation that further weakens this barrier.
Filaggrin builds that barrier. It builds stronger skin cells, locks in moisture, and keeps irritants out.
L-histidine feeds filaggrin. It's the key building block your body needs to rebuild the skin barrier.
Genetics can work against you. Some people are wired to produce less filaggrin from the start.
