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For a Stronger Skin Barrier

Reduce water loss & improve integrity

Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Supplement facts label on a light gray background
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)
Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)

Skin Barrier Support L-Histidine Supplement

363 reviews 30-DAY SUPPLY
$59

Age: 13-17 years

3-12 months

1-3 years

4-12 years

13-17 years

18+ years

The ANTÜ Skin Barrier Support Supplement feeds filaggrin production with L-histidine, the amino acid your body needs to rebuild the skin barrier. When filaggrin levels are low, the barrier breaks down, letting moisture out and irritants in. This daily supplement works from within to provide the raw materials your skin needs to repair itself.

Paired with our M3+ antioxidant complex to reduce oxidative stress and support gut barrier health, ANTÜ addresses the skin barrier from the inside and out.

Teens: 1 sachet daily mixed into water. Adults: 2 sachets daily mixed into water.

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Real Codex Customers

After treatment After
Before treatment Before

Clinical Results

34%

decrease in average SCORAD in 8 weeks*

93%

decrease in average SCORAD in 8 weeks when paired with Bia Eczema Relief Lotion and Bia Unscented Soap**

97%

decrease in NRS (itch) in 8 weeks when paired with Bia Eczema Relief Lotion and Bia Unscented Soap**

* Double-blind study, 24 men and women, aged 18+ with mild to moderate atopic dermatitis over 112 days (Curapel, UK, 2017). Publication: http://dx.doi.org/10.2147/CCID.S146760
** Open label study, 33 men and women, aged 18+ with mild to moderate atopic dermatitis over 56 days (Eurofins, Poland, 2024). Publication: https://jintegrativederm.org/doi/10.64550/joid.ymnj5r09

Chart showing Filaggrin expression levels and eczema risk on a blue background

Build a Stronger Skin Barrier with Skin Barrier Support L-Histidine Supplement (Teen/Adult: 13+)

We know that classic eczema (atopic dermatitis), is a chronic skin condition where the skin barrier is weakened or disrupted. This can lead to a cycle of inflammation, redness, and itchiness. Scratching further weakens the skin barrier, which can worsen the condition and lead to infections.

The filaggrin gene (filament aggregating protein) plays an important role in maintaining skin barrier integrity, preventing de-hydration, as well as preventing pathogens and irritants from getting through the skin barrier.  Those with eczema may have fewer copies of the FLG gene, resulting in less functional filaggrin protein in the epidermis, less natural moisturization factor, and a leakier skin barrier. [image reference: DOI 10.1111/bjd.14997] This in turn increases water loss (skin de-hydration) and pH, inhibiting lipid-generating enzymes, which decreases skin cell adhesion (tight junctions/corneodesmosomes), deregulates skin turnover (desquamation), and decreases ceramides (the lipid matrix).



  • Vegan Society Logo

    Plant-Based

  • SAFE logo

    S.A.F.E

The Antü Skin Barrier Support Supplement by Codex stands out with M3, a proprietary blend targeting skin resilience, and L-histidine, an amino acid that plays a critical role in repairing the barrier. Together, they help fortify the skin against environmental stressors while promoting a balanced, healthy complexion.

- Trisha Khanna, MD

01 / 03
- Trisha Khanna, MD

The Antü Skin Barrier Support Supplement contains a remarkable combination of ingredients to strengthen the skin barrier. The L-histidine alone has been shown to help heal damaged skin, but together with other anti-inflammatory and supportive botanicals make this a truly unique product. The lotion has also been studied in those with sensitive skin, and is packed with active botanicals designed for impaired skin.

- Dr. Peter Lio, MD, Pediatric Dermatologist, Northwestern Medicine

02 / 03
- Dr. Peter Lio, MD, Pediatric Dermatologist, Northwestern Medicine

For the Bia eczema collection, we have clinical results that conclusively prove the significant treatment synergy of topical and supplements in repairing the gut and skin barriers, as well as alleviating itch.

Professor Philippe Humber MD FAAD

03 / 03
Professor Philippe Humber MD FAAD

Frequently Asked Questions

Daily dietary supplement formulated to address skin barrier deterioration from stress and the exposome (allergens, pollution, UV, smoking, lifestyle). It helps restore a weakened skin barrier to reduce trans-epidermal water loss, increase hydration, and improve barrier cohesion (desquamation).

Key actives include:   

  • L-Histidine: skin soothing amino acid which supports the repair of damaged skin barrier. It is used by the body to make the protein filaggrin, a key building block of the skin barrier, as well as make Natural Moisturization Factor (NMF) used by the skin to help attract and retain moisture.
  • M3+ [maqui, matico, murtilla]: adaptogenic antioxidant phyto-complex containing potent anthocyanins, flavonols, and flavonoids that help to soothe irritation, reduce inflammation, and support the gut and skin barriers against oxidative stress and pollution.

In self-assessments during our clinical trials:
• 100% agree skin condition improved
• 97% agree skin felt soothed, less dry, and itched less
• 93% agree erythema (redness) was reduced

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